Axovant Sciences Ltd., formerly Roivant Neurosciences Ltd., incorporated on October 31, 2014, is a clinical-stage biopharmaceutical company focused on acquiring, developing and commercializing therapeutics for the treatment of dementia. The Company focuses on developing a pipeline of product candidates to address the cognitive, functional and behavioral aspects of dementia and related neurological disorders.
The Company's focus is to develop its lead product candidate, Intepirdine, which is for the treatment of Alzheimer's disease and dementia with Lewy bodies (DLB). The Company also focuses on developing its second product candidate, Nelotanserin, which is for the treatment of visual hallucinations in patients with DLB and rapid eye movement (REM) behavior disorder (RBD) in patients with DLB.
Intepirdine
The Company's lead product candidate, Intepirdine, is a selective 5-hydroxytryptamine 6 (5-HT6) receptor antagonist. The Company has initiated a multi-center, double-blind and placebo-controlled confirmatory Phase III clinical study of Intepirdine, entitled as MINDSET, for the treatment of mild-to-moderate Alzheimer's disease. The Company is evaluating Intepirdine in patients with mild-to-moderate Alzheimer's disease and it intends to develop Intepirdine to address other forms of dementia, such as dementia with DLB. In addition, Intepirdine has antagonist activity against the 5-HT2A receptor, which has been implicated in the pathophysiology of visual hallucinations and other behavioral disturbances affecting patients with DLB.
Nelotanserin
The Company's Nelotanserin is a selective 5-HT2A receptor inverse agonist. Nelotanserin has been evaluated in approximately seven clinical studies. It has initiated a Phase II clinical study of Nelotanserin in DLB and Parkinson's disease dementia (PDD) patients suffering from visual hallucinations.
Clarendon House, 2 Church Street
The company trades on NMS exchange. The company headquarter is located in Scottsdale, United States. The company was established in the 1993.| Ticker | AXON |
| Long Name | Axon Enterprise, Inc. |
| Short Name | Axon Enterprise, Inc. |